Ketamine Treatment Types

There are several ways ketamine therapy is administered. Each method has different costs, protocols, and efficacy profiles. Compare options and find providers near you.

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IV Ketamine Infusion

Intravenous ketamine infusion delivers ketamine directly into the bloodstream for the fastest onset of therapeutic effec...

$400–$800 per session Off-label
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Spravato (Esketamine)

Spravato (esketamine) is an FDA-approved nasal spray for treatment-resistant depression and major depressive disorder wi...

$590–$885 per session FDA-approved (2019)
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IM Ketamine Injection

Intramuscular (IM) ketamine injection offers similar efficacy to IV ketamine with a simpler, faster administration metho...

$250–$500 per session Off-label
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Ketamine-Assisted Psychotherapy

Ketamine-Assisted Psychotherapy (KAP) combines sub-anesthetic doses of ketamine with psychotherapy for enhanced therapeu...

$500–$1,500 per session Off-label
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Oral & Sublingual Ketamine

Oral and sublingual ketamine (lozenges or troches) can be prescribed for at-home use, often through telehealth providers...

$100–$250 per session Off-label
Comparison

Treatment Comparison at a Glance

Treatment Cost/Session Protocol FDA Status Insurance
IV Ketamine Infusion $400–$800 6 infusions, 2–3 weeks Off-label Rarely covered
Spravato (Esketamine) $590–$885 2x/week then taper FDA-approved Often covered
IM Injection $250–$500 6 sessions, 2–3 weeks Off-label Rarely covered
KAP $500–$1,500 6+ sessions with therapist Off-label Rarely covered
Oral/Sublingual $100–$250 Monthly, at-home Off-label Not covered